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The E3 ubiquitin ligase NLA postively regulates cold tolerance and negatively regulates phosphate uptake in maize, and a genetically engineered variant of this enzyme leads to improved cold tolerance and enhanced phosphate uptake, improving yield in field trials.
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For implementers, backpressure adds complexity without providing guarantees. The machinery to track queue sizes, compute desiredSize, and invoke pull() at the right times must all be implemented correctly. However, since these signals are advisory, all that work doesn't actually prevent the problems backpressure is supposed to solve.
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